[Comparative pharmacokinetic research on amoxicillin in agricultural animals]

Described is the pharmacokinetic of amoxycillin following i/v and oral administration to calves, pigs, and rabbits at the rate of 10 mg per kg of body mass and to turkeys at 30 mg/kg body mass. The pharmacokinetic was found to be of first order, whereas a bispatial model was applicable after i/v introduction of the sodium salt and a monospatial model--following the oral administration of amoxycillin trihydrate. Discussed are the differences in the absorption, distribution, and excretion of the antibiotic as affected by the mode of application and the species peculiarities of the animals.