Related Experiment Video
Updated: Jul 8, 2025
Application of Hemostatic Devices in Laparoscopic Hepatectomy
Published on: April 19, 2022
Lower myocardial infarction and all-cause mortality with laparoscopic cholecystectomy compared with open
Taft Keele1, Mehrtash Hashemzadeh1, Mohammad Reza Movahed1,2
1University of Arizona, College of Medicine, Phoenix 85004, AZ, USA.
Insights
Open cholecystectomy (OC) is linked to higher inpatient mortality and myocardial infarction rates compared to laparoscopic cholecystectomy (LC). This study analyzed national data to compare outcomes between the two surgical procedures.
Area of Science:
- Surgical outcomes research
- Cardiovascular event analysis
- Health services research
Background:
- Cholecystectomy is a common surgical procedure.
- Laparoscopic cholecystectomy (LC) is often preferred over open cholecystectomy (OC).
- Inpatient outcomes following OC versus LC require further comparative analysis.
Purpose of the Study:
- To compare inpatient outcomes between open cholecystectomy (OC) and laparoscopic cholecystectomy (LC).
- To assess the association of OC versus LC with major adverse events, including myocardial infarction and mortality.
Main Methods:
- Utilized the National Inpatient Samples database for data from 2010-2014.
- Compared outcomes for 340,999 LC patients and 68,529 OC patients.
- Performed multivariate analysis to adjust for confounding factors.
Main Results:
- Open cholecystectomy (OC) was associated with significantly higher prevalence of ST-elevation myocardial infarction (STEMI) and non-STEMI compared to laparoscopic cholecystectomy (LC).
- OC demonstrated a substantially higher all-cause inpatient mortality rate (3.4% vs. 0.4%) compared to LC.
- Multivariate analysis confirmed OC as an independent risk factor for STEMI, non-STEMI, and all-cause inpatient mortality.
Conclusions:
- Open cholecystectomy (OC) is independently associated with increased risks of myocardial infarction (STEMI and non-STEMI) and all-cause inpatient mortality when compared to laparoscopic cholecystectomy (LC).
- These findings suggest that LC may offer a safer alternative for patients undergoing cholecystectomy.
Abstract:
Aim: We compared inpatient outcome data of open (OC) versus laparoscopic cholecystectomy (LC). Patients & methods: We used the National Inpatient Samples database from 2010-2014. Results: LC was done in 340,999 and OC in 68,529 OC patients. In 2010, ST-elevation myocardial infarction (STEMI) prevalence was 0.2 versus 0% (OR: 3.1, CI: 1.7-5.5; p < 0.001), non-STEMI 1 versus 0.4% (OR: 2.5 CI: 2.0-3.0; p < 0001), mortality 3.4 versus 0.4% (OR: 9.2, CI: 7.9-10.6; p < 0001). After multivariate adjustment, OC remained independently associated with STEMI, non-STEMI and all-cause inpatient mortality (mortality multivariate OR: 6.4, CI: 5.5-7.4; p < 0001, STEMI OR: 2.2. CI: 1.2-3.9; p = 0.007, non-STEMI OR: 1.5, CI: 1.3-1.9; p < 0001). Conclusion: OC is independently associated with STEMI, non-STEMI and all-cause inpatient mortality compared with LC.
