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Published on: September 22, 2023
IMMUNE-INFLAMMATORY-ENDOCRINE REGULATION DISORDERS IN CHILDREN WITH CORONAVIRUS INFECTION
Olesya M Horlenko1, Khrystyna A Hechko1, Lyubomyra B Prylypko1
1UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
Insights
Children with Coronavirus infection showed significant immune system and metabolic changes. Key findings include elevated immunoglobulin levels, C-reactive protein, and C-peptide, alongside altered thyroid hormone and lipid profiles.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Biochemistry
- Immunology
Background:
- Coronavirus infection in children can disrupt homeostasis.
- Understanding metabolic and immune markers is crucial for managing pediatric COVID-19.
Purpose of the Study:
- To investigate the links between homeostatic disorders and indicator imbalances in children with Coronavirus infection.
- To identify key biomarkers associated with COVID-19 in pediatric patients.
Main Methods:
- A clinical and laboratory study involving 50 children with Coronavirus infection undergoing outpatient treatment.
- Analysis of various biochemical and immunological markers, including liver enzymes, immunoglobulins, C-reactive protein, C-peptide, thyroid hormones, and lipids.
Main Results:
- Significant increases observed in Direct bilirubin (3x), Alanine aminotransferase (1.7x), Immunoglobulin G (12.3x), Immunoglobulin E (4.6x), Immunoglobulin M (3.4x), C-reactive protein (3.1x), and C-peptide (3.8x).
- Negative correlations found between T3 and Procalcitonin/Creatinine; T4 and Total cholesterol (r=-0.65).
- Positive correlations noted between Leptin and Alanine aminotransferase (r=0.48) and C-peptide (r=0.39).
Conclusions:
- Children with Coronavirus infection exhibit marked elevations in immunoglobulins (IgG, IgE, IgM), C-reactive protein, and C-peptide.
- Thyroid stimulating hormone levels were significantly decreased (4.7x).
- Strongest correlations identified were between T4 and Total cholesterol, and Leptin with Alanine aminotransferase and C-peptide, highlighting metabolic and inflammatory pathway involvement.
Objective:
The aim: To study the of homeostasis links desorder and indicators imbalance in children with Coronavirus infection.
Patients And Methods:
Materials and methods: A clinical and laboratory study was conducted in children (50 persons) with Coronavirus infection. The children were used outpatient treatment.
Results:
Results: It was found that Direct bilirubin was increased in 3 times (10.55±7.67 vs. 3.63±0.49 μmol/l, p<0.01), Alanine aminotransferase - in 1.7 times (37,02±20.53 vs. 21.90±1.82 IU/l, p<0.01). An levels increassng of Ig G - in 12.3 times, Ig E - in 4.6 times, Ig M - in 3.4 times was observed. The CRP level was increased in 3.1 times (8.76 ± 2.16 vs. 2.54 ± 0.53 mg/l, p< 0.01), C-peptide (4.65±1.67 vs. 1.23±0.08 ng/ml, p<0.01) - in 3.8 times. Negative correlations of T3 with Procalcitonin (r=-0.30) and Creatinine (r=-34) were revealed. T4 values are correlated with Total cholesterol (r=-0.65) and Creatinine (r=0.29). Leptin was presented positive correlations with Alanine aminotransferase (r=0.48) and with C-peptide (r=0.39).
Conclusion:
Conclusions: There was an increase in the Ig G levels in 12.3 times, Ig E - in 4.6 times, and the Ig M level - in 3.4 times. The Thyroid stimulating hormone level was significantly lower (in 4.7 times). An increase in the C-reactive protein levels (in 3.1 times) and C-peptide (in 3.8 times) was observed. It should be noted that the strongest negative correlation between T4 and Total cholesterol (r=-0.65) and the highest positive correlation between Leptin and Alanine aminotransferase (r=0.48) and C-peptide (r=0. 39).
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