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Elucidating the relationship between breast cancer and brain cortical structure: a Mendelian randomization study
Yilong Lin1, Songsong Wang2, Liyi Zhang1
1Department of Breast Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361003, China.
Cerebral Cortex (New York, N.Y. : 1991)
|December 19, 2023
Summary
Estrogen receptor-negative breast cancer is linked to reduced brain surface area and thickness in specific cortical regions. This finding highlights potential cerebral atrophy associated with this breast cancer subtype.
Area of Science:
- Neuroscience
- Oncology
- Genetics
Background:
- Cancer-associated cognitive impairment affects breast cancer survivors' quality of life.
- Understanding the link between breast cancer subtypes and brain structure is crucial.
Conclusions:
- Breast cancer, particularly the estrogen receptor-negative subtype, is associated with alterations in cerebral cortical structure.
- Estrogen receptor-negative breast cancer may lead to more widespread cerebral atrophy.
- Further research is warranted to understand the mechanisms and implications of these findings.
