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Related Experiment Video

Updated: Jul 8, 2025

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Circulating Plasma Oxytocin Level Is Elevated by High-Intensity Interval Exercise in Men.

Hayato Tsukamoto, Niels D Olesen, Lonnie G Petersen

  • 1Institute of Advanced Research for Sport and Health Science, Ritsumeikan University, Shiga, JAPAN.

Medicine and Science in Sports and Exercise
|December 20, 2023
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Summary

Repeated high-intensity interval exercise (HIIE) increases circulating oxytocin (OT) levels in men. This study found no change in cerebral oxytocin release, suggesting OT acts as an exercise-induced factor (exerkine).

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Area of Science:

  • Exercise Physiology
  • Neuroendocrinology
  • Human Physiology

Background:

  • Oxytocin (OT) is a hormone primarily synthesized in the hypothalamus.
  • Exerkines are signaling molecules released during exercise that mediate health benefits.
  • The role of OT in response to exercise, particularly high-intensity interval exercise (HIIE), is not fully understood.

Purpose of the Study:

  • To investigate the effect of repeated HIIE on plasma oxytocin (OT) concentration in healthy men.
  • To assess the difference between arterial and internal jugular venous OT concentrations to evaluate cerebral OT release.
  • To test the hypothesis that HIIE augments both cerebral and circulating OT concentrations.

Main Methods:

  • Fourteen healthy men underwent two identical bouts of HIIE, each including a warm-up and four high-intensity intervals.
  • Blood samples were collected from the radial artery and internal jugular vein to measure OT concentrations.
  • HIIE consisted of 5-minute warm-up, followed by four 4-minute intervals at 80%-90% maximal workload interspersed with 3-minute recovery periods.

Main Results:

  • Both HIIE bouts significantly increased arterial (OT ART) and internal jugular venous (OT IJV) oxytocin concentrations.
  • No significant difference was observed in the OT ART-IJV concentration, indicating no change in net cerebral OT release.
  • The increase in OT levels during HIIE was consistent between the first and second exercise bouts.

Conclusions:

  • Circulating oxytocin levels rise during high-intensity interval exercise in men, irrespective of exercise volume.
  • Cerebral oxytocin release, measured via the internal jugular vein, did not change significantly.
  • These findings suggest that oxytocin may function as an exerkine, a substance released by exercise that influences bodily functions.