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Related Experiment Video

Updated: Jul 8, 2025

Blood Flow Imaging with Ultrafast Doppler

Blood Flow Imaging with Ultrafast Doppler

Published on: October 14, 2020

Quantifying tissue properties and absolute hemodynamics using coherent spatial imaging.

Christian Crouzet¹, Cody E Dunn^1,2, Bernard Choi^1,2,3,4

¹University of California, Irvine, Beckman Laser Institute and Medical Clinic, Irvine, California, United States.

Journal of Biomedical Optics

|December 20, 2023

Summary

This summary is machine-generated.

This study introduces Coherent Spatial Imaging (CSI), an affordable optical technology for measuring hemodynamic parameters like blood flow and hemoglobin concentration. CSI offers comprehensive physiological data, potentially improving health assessments.

Keywords:

blood flow diffuse optics hemoglobin concentrations optical properties

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Last Updated: Jul 8, 2025

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Published on: October 2, 2021

Area of Science:

Biomedical Optics
Physiological Monitoring
Optical Imaging

Background:

Accurate hemodynamic monitoring is vital for health assessment.
Current optical methods for absolute hemoglobin concentration are often expensive and bulky.
Speckleplethysmography (SPG) offers a promising avenue for optical hemodynamic measurements.

Purpose of the Study:

To develop an affordable optical technology for measuring tissue absorption, scattering, hemoglobin concentrations, tissue oxygen saturation, and blood flow.
To create a novel system integrating reflectance spectroscopy and laser speckle imaging.
To validate the new system against established optical techniques.

Main Methods:

Coherent Spatial Imaging (CSI) was developed by integrating reflectance spectroscopy and laser speckle imaging.
Phantom-based measurements validated CSI against spatial frequency domain imaging (SFDI).
In vivo occlusion experiments compared CSI with diffuse optical spectroscopy/diffuse correlation spectroscopy (DOS/DCS).

Main Results:

CSI demonstrated agreement with SFDI for tissue optical properties in phantoms.
CSI and DOS/DCS showed comparable trends in hemodynamic parameters during arterial occlusion.
Both methods indicated decreased blood flow during venous occlusion, with minor differences.

Conclusions:

Coherent Spatial Imaging (CSI) provides a cost-effective solution for comprehensive hemodynamic assessment.
CSI technology has the potential to improve the measurement of blood pressure, oxygen saturation, and metabolism.
This affordable optical technology can aid in detecting physiological dysfunction.