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Skin Rash as a Side Effect of Bortezomib: A Case Report.
Marah Khaldy1, Saeed Hamdan2, Mohammad Amar2
1Internal Medicine, Augusta Victoria Hospital, Jerusalem, PSE.
Cureus
|December 20, 2023
Summary
A rare skin rash, an allergic reaction to bortezomib (Velcade) used for multiple myeloma, can occur. Early recognition and corticosteroid treatment are key for managing this side effect.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Bortezomib is a proteasome inhibitor used for multiple myeloma.
- Common side effects include nausea, vomiting, neuropathic pain, and hemorrhage.
- Cutaneous manifestations are rare but can occur.
Observation:
- A 72-year-old female with relapsed multiple myeloma on the VRD protocol (bortezomib, lenalidomide, dexamethasone) developed a widespread, itchy, erythematous rash.
- The rash initially appeared on the soles and palms before generalizing.
- Skin biopsy confirmed an allergic reaction as the cause of the lesions.
Findings:
- The patient was admitted for sepsis and subsequently died.
- Cutaneous rash is a rare but possible side effect of bortezomib.
- The presentation and onset of bortezomib-induced skin rashes can be variable.
Implications:
- This case underscores the need for vigilance regarding rare dermatological adverse events associated with bortezomib.
- Prompt recognition and management of skin reactions are crucial.
- Corticosteroids are the primary treatment for such allergic reactions.
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