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Hepatotoxicity Induced by Azole Antifungal Agents: A Review Study

Amin Rakhshan1, Bardia Rahmati Kamel2, Ali Saffaei1

  • 1Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Iranian Journal of Pharmaceutical Research : IJPR
|December 20, 2023
PubMed
Abstract

Insights

Azole antifungal drugs can cause liver injury. This review summarizes studies on azole antifungal-induced hepatotoxicity, recommending cautious use and monitoring in patients with liver disease.

Area of Science:

  • Medical Mycology
  • Pharmacology
  • Hepatology

Background:

  • Fungal infections are prevalent, with azole antifungals being a common treatment.
  • Drug-induced liver injury is a significant concern, particularly with azole antifungal agents.

Purpose of the Study:

  • To systematically review and summarize the existing literature on hepatotoxicity induced by azole antifungal drugs.
  • To consolidate findings on the effects and mechanisms of azole antifungal-induced liver injury.

Main Methods:

  • A systematic literature search was conducted on PubMed, Google Scholar, and Science Direct.
  • English scientific papers published before April 1, 2022, were included; full-text unavailability or non-English content led to exclusion.

Main Results:

  • The majority of reviewed studies documented the occurrence of hepatotoxicity associated with azole antifungal agents.
  • Mechanisms underlying azole antifungal-induced liver injury have been described in the literature.

Conclusions:

  • Prescribing azole antifungals requires caution, especially in patients with pre-existing liver conditions.
  • Close patient monitoring for hepatotoxicity is advised; further research is needed for safer, cost-effective drug selection.
Keywords:
Adverse EffectsAntifungalsAzolesHepatotoxicityLiver Injury

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