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Copper(II) and Nickel(II) Complexes Derived from Isostructural Bromo- and Fluoro-Containing Bis-Schiff Bases:
Ke-Sheng Cao1, Ling-Wei Xue2, Qiao-Ru Liu3
1. 58051023@qq.com.
Acta Chimica Slovenica
|December 21, 2023
Summary
New copper and nickel Schiff base complexes were synthesized and structurally characterized. These metal complexes showed varying biological activity against common bacteria and fungal strains.
Area of Science:
- Coordination Chemistry
- Materials Science
- Medicinal Chemistry
Background:
- Schiff base ligands are versatile building blocks in coordination chemistry.
- Metal complexes exhibit diverse biological activities, making them candidates for antimicrobial agents.
Purpose of the Study:
- To synthesize and characterize novel mononuclear copper(II) and nickel(II) complexes.
- To investigate the structural properties of these metal complexes.
- To evaluate the antimicrobial efficacy of the synthesized complexes against pathogenic bacteria and fungi.
Main Methods:
- Synthesis of mononuclear copper(II) and nickel(II) complexes using Schiff base ligands.
- Structural characterization via spectroscopy (e.g., UV-Vis, IR) and elemental analysis.
- X-ray single crystal diffraction for detailed structural determination.
- Biological activity assays against Staphylococcus aureus, Escherichia coli, and Candida albicans.
Main Results:
- Four mononuclear complexes, [CuLa] (1), [NiLa] (2), [NiLa]·CH3OH (2·CH3OH), and [NiLb] (3), were successfully prepared.
- X-ray diffraction confirmed square planar coordination geometry around the metal centers (Cu(II) and Ni(II)) involving phenolate oxygens and imine nitrogens.
- The complexes displayed varying degrees of biological activity against the tested bacterial and fungal strains.
Conclusions:
- The study successfully synthesized and characterized novel copper and nickel Schiff base complexes.
- The structural analysis revealed square planar coordination, typical for these types of complexes.
- The biological evaluation provides preliminary data on the antimicrobial potential of these metal complexes, warranting further investigation.
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