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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Safety of Non-Operating Room Anesthesia With Propofol Sedation in Three Pediatric Patients With Central Sleep Apnea

Fiona Gruzmark1, Nadia Shaikh1, Shane C Rainey2

  • 1Department of Pediatrics (FG, NS, KH), University of Illinois College of Medicine at Peoria, and OSF Healthcare Children's Hospital of Illinois, Peoria, IL.

The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG
|December 22, 2023
PubMed

Insights

Deep sedation with propofol may be safe for children with central sleep apnea undergoing procedures like brain imaging. This approach could avoid general anesthesia and advanced airway placement, offering a safer alternative for this patient group.

Area of Science:

  • Pediatric Anesthesiology
  • Sleep Medicine
  • Neurology

Background:

  • Children with central sleep apnea (CSA) often need sedation for diagnostic procedures.
  • The safety of deep sedation without airway protection in pediatric CSA patients is not established.
  • Obstructive sleep apnea (OSA) is a contraindication for deep sedation with propofol.

Purpose of the Study:

  • To evaluate the safety and feasibility of deep sedation using propofol for brain imaging in pediatric patients with central sleep apnea.
  • To determine if deep sedation without an advanced airway is a viable option for this population.

Main Methods:

  • A case series design was employed.
  • Three pediatric patients diagnosed with central sleep apnea underwent deep sedation with propofol for brain imaging.
  • Procedures were conducted in a non-operating room setting.

Main Results:

  • All three patients tolerated deep sedation with propofol without any complications.
  • Patients requiring home oxygen received it during the procedure.
  • No instances of apnea, desaturation, or respiratory distress were observed.

Conclusions:

  • Deep sedation with propofol appears to be safe in pediatric patients with central sleep apnea.
  • This sedation method may be a suitable alternative to general anesthesia and invasive airway management.
  • Further studies are warranted to confirm these findings in a larger cohort.

Keywords:
anesthesiaapneachildnon-operating room anesthesia (NORA)patient safetypropofol

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