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Related Concept Videos

Testosterone: Functions and Regulation01:26

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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
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Testosterone Pellet Use in Transgender Men.

Kwan Cheng1, Aren Skolnick1

  • 1Department of Endocrinology, Diabetes and Metabolism, Northwell Health, New Hyde Park, New York, USA.

Transgender Health
|December 22, 2023
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Summary
This summary is machine-generated.

Testosterone pellets are effective for transgender men, maintaining hormone levels and achieving desired effects like amenorrhea. However, high rates of polycythemia and pellet extrusion were observed, requiring cautious use.

Keywords:
erythrocytosistestosterone pellettransgendertransgender man

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Area of Science:

  • Endocrinology
  • Transgender Health
  • Pharmacology

Background:

  • Testosterone therapy is crucial for transgender men.
  • Exploring diverse testosterone delivery methods is essential.
  • Testosterone pellets offer a long-acting option.

Purpose of the Study:

  • To evaluate the efficacy of testosterone pellets in transgender men.
  • To assess short-term adverse effects of testosterone pellet therapy.
  • To expand therapeutic choices for transgender men.

Main Methods:

  • Retrospective study of 30 transgender men.
  • Initiated testosterone pellets at 675-825 mg per cycle.
  • Adjusted dosage based on testosterone levels (1-6 months post-insertion).

Main Results:

  • Pharmacokinetics similar to cisgender men.
  • Therapeutic testosterone levels (300-800 ng/dL) maintained for ~4 months.
  • 100% achieved amenorrhea and voice deepening.
  • High rates of polycythemia (46.67%) and pellet extrusion (13.33%).
  • Low rates of hematoma (6.67%) and cellulitis (3.33%).

Conclusions:

  • Testosterone pellets are a viable alternative for transgender men.
  • Caution advised for patients with polycythemia or thromboembolic risk.
  • Further monitoring for adverse events like polycythemia is warranted.