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[Oral premedication with diazepam].

R Ramboatiana, L Monnin, F Thévenon

    Annales Francaises D'Anesthesie Et De Reanimation
    |January 1, 1986
    PubMed
    Summary
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    Oral diazepam premedication for appendicectomy patients did not significantly reduce anxiety compared to intramuscular administration. Oral route did not increase risks associated with gastric contents, supporting its wider use in elective surgeries.

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Surgical Premedication

    Background:

    • Preoperative anxiety and gastric status are critical factors in surgical patient management.
    • Diazepam is a commonly used anxiolytic agent for surgical premedication.
    • The route of administration (oral vs. intramuscular) may influence diazepam's efficacy and safety.

    Purpose of the Study:

    • To compare the anxiolytic effects of oral versus intramuscular diazepam in patients undergoing appendicectomy.
    • To evaluate the impact of oral versus intramuscular diazepam on gastric volume and acidity.
    • To determine the safety of oral premedication regarding aspiration risk.

    Main Methods:

    • A double-blind study design was employed.
    • Patients scheduled for appendicectomy were randomized into two groups: oral diazepam and intramuscular diazepam.

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  • Clinical effects assessed included anxiolysis, gastric content volume, and gastric acidity (pH).

    • Main Results:

    • No significant difference in anxiety levels was observed between the oral and intramuscular diazepam groups.
    • Gastric content volume and acidity showed no significant variations between the two administration routes.
    • Oral premedication was found not to increase the risk of pulmonary aspiration.

    Conclusions:

    • Oral diazepam provides comparable anxiolysis to intramuscular administration for appendicectomy.
    • The oral route is a safe alternative for diazepam premedication in elective adult surgeries, with no increased aspiration risk.
    • Wider adoption of oral premedication is recommended due to its pharmacological benefits and safety profile.