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Bio-Impedance Spectroscopy of Retained Cells Using a Micro-Perforated Sensing Membrane Filtrating Whole Blood Samples

Matthieu Sagot^1,2, Elise Bou², David Bourrier¹

¹LAAS-CNRS, Université de Toulouse, CNRS, INSA, INPT, 31400 Toulouse, France.

|December 22, 2023

Summary

This study presents a microdevice with electrodes for real-time blood cell capture detection during filtration. This innovation enables efficient, large-volume blood processing and monitoring for various clinical applications.

Keywords:

blood filtration impedance spectroscopy microfluidics

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Area of Science:

Biomedical Engineering
Microfluidics
Biosensing

Background:

Blood filtration is crucial for clinical applications like cytapheresis and liquid biopsy.
Current methods lack real-time monitoring capabilities during high-flow filtration.

Purpose of the Study:

To develop a microfabricated device for in situ, real-time detection of cellular material during blood filtration.
To enable monitoring of blood filtration processes at high flow rates.

Main Methods:

Fabrication of a micro-perforated membrane integrated with sensing microelectrodes.
Ex vivo whole blood filtration experiments at flow rates up to 11.5 mL/min.
In situ electrical impedance monitoring of microelectrodes to detect cell capture.

Main Results:

Demonstrated reliable electrical signal measurement in whole blood at high flow rates.
Successfully characterized the accumulation of living circulating cells on the membrane.
Validated the device's capability for large-volume sample processing.

Conclusions:

The developed microdevice enables real-time monitoring of cellular material capture during blood filtration.
This technology supports efficient, large-volume blood processing for clinical applications.
In situ electrical impedance sensing offers a promising approach for blood filtration process characterization.