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Gradient Guided-Mode Resonance Biosensor with Smartphone Readout.

Ting-Zhou Lin1, Cheng-Hao Chen1, Yuan-Pei Lei1

  • 1Department of Mechanical Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.

Biosensors
|December 22, 2023
PubMed
Summary
This summary is machine-generated.

This study presents a novel smartphone biosensor using a gradient grating period guided-mode resonance (GGP-GMR) sensor for biomolecule detection. The system offers a portable and cost-effective alternative to lab instruments, achieving low detection limits for sucrose, albumin, and creatinine.

Keywords:
albumincreatinineguided-mode resonanceoptical biosensorsmartphone biosensor

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Area of Science:

  • Biomedical Engineering
  • Optical Sensors
  • Point-of-Care Diagnostics

Background:

  • Smartphone integration with biosensors offers a portable and cost-effective alternative to traditional laboratory equipment.
  • Guided-mode resonance (GMR) sensors provide high sensitivity for detecting biomolecules through optical shifts.

Purpose of the Study:

  • To develop and validate a novel smartphone-based biosensor system utilizing a gradient grating period guided-mode resonance (GGP-GMR) sensor.
  • To demonstrate the potential of this system for quantitative and multiplexed detection of various biomolecules.

Main Methods:

  • A GGP-GMR sensor was designed, where gratings block specific resonant wavelengths, creating a observable dark band.
  • The sensor was illuminated by an LED, and transmitted light was captured and analyzed by a smartphone.
  • The system was tested for detecting sucrose solutions and simultaneously for albumin and creatinine.

Main Results:

  • A limit of detection (LOD) of 1.50 × 10-3 RIU was achieved for sucrose.
  • Multiplexed detection of albumin and creatinine demonstrated LODs of 1.18 μg/mL and 20.56 μg/mL, respectively.
  • The smartphone interface successfully displayed the results, confirming system functionality.

Conclusions:

  • The proposed smartphone-based GGP-GMR biosensor system is a viable, portable, and sensitive platform for biomolecule detection.
  • This technology has the potential to replace expensive laboratory instruments in various diagnostic applications.
  • The demonstrated multiplexing capability enhances its utility for analyzing complex biological samples.