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Cytokines and Epidermal Lipid Abnormalities in Atopic Dermatitis: A Systematic Review
Parth R Upadhyay1, Lucia Seminario-Vidal1, Brian Abe1
1Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
Cells
|December 22, 2023
Summary
Atopic dermatitis (AD) involves skin barrier dysfunction, driven by immune system imbalances. This review highlights how cytokines, particularly type 2, significantly impact skin lipids in AD, guiding future therapies.
Area of Science:
- Dermatology
- Immunology
- Biochemistry
Background:
- Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition marked by intense itching and recurrent lesions.
- Key pathophysiologic features include epidermal barrier defects, immune cell dysregulation, and microbiome alterations.
- Cytokines mediate complex interactions between these factors, with epidermal barrier dysfunction being a central characteristic.
Approach:
- A systematic literature review was performed using PubMed, covering studies from the inception of the database to September 5, 2023.
- The review focused on defining the role of cytokines in stratum corneum lipid abnormalities within the context of atopic dermatitis.
- Biomedical literature was analyzed to understand cytokine influence on skin barrier lipids.
Key Points:
- Type 2 cytokines play a prominent role in epidermal lipid alterations in AD skin, aligning with the condition's TH2 immune bias.
- Cytokines associated with TH1 and TH17 responses were also found to impact barrier lipids.
- The study emphasizes the significant influence of various cytokines on the skin's lipid structure.
Conclusions:
- Understanding the specific roles of different cytokines in AD-related lipid abnormalities and barrier dysfunction is crucial.
- Targeting these cytokine-lipid interactions may lead to novel therapeutic strategies for restoring barrier homeostasis in AD patients.
- Further research into cytokine-mediated lipid regulation can advance the development of effective AD treatments.
Keywords:
atopic dermatitisbarrier dysfunctionceramidescholesterolcytokinesfatty acidlipidsskin barrierMore Related Videos
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