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The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
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Porous Polylactide Microparticles as Effective Fillers for Hydrogels.

Yuriy D Zagoskin1, Yana E Sergeeva1,2, Yuliya S Fomina1

  • 1National Research Centre "Kurchatov Institute", 123182 Moscow, Russia.

Biomimetics (Basel, Switzerland)
|December 22, 2023
PubMed
Summary

Researchers developed high-strength composite hydrogels using porous polylactide (PLA) microparticles. These advanced hydrogels mimic natural tissue biomechanics and offer controlled release of biomolecules.

Keywords:
C-phycocyanincollagenhydrogelpolylactideporous materialsscanning acoustic microscopy

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Hydrogels are crucial in regenerative medicine but often lack mechanical strength.
  • Developing composite hydrogels with tunable mechanical properties is essential for mimicking native tissues.

Purpose of the Study:

  • To create high-strength composite hydrogels using highly porous polylactide (PLA) microparticles.
  • To investigate the impact of porous PLA microparticles on hydrogel mechanical properties and biomolecule release.
  • To develop materials that mimic the biomechanics and function of living tissues.

Main Methods:

  • Composite hydrogels were fabricated by mixing collagen or chitosan-genipin with highly porous polylactide (PLA) microparticles (50-75 µm, >98% porosity).
  • The elastic modulus of the hydrogels was measured at varying concentrations of PLA microparticles.
  • PLA microparticles were loaded with C-phycocyanin to evaluate biomolecule release profiles.

Main Results:

  • Hydrogel elastic modulus increased significantly with PLA microparticle concentration, ranging from 80 kPa to 1.8 MPa for collagen hydrogels and 75 kPa to 900 kPa for chitosan-genipin hydrogels.
  • Increased mechanical strength was achieved with decreased material density (increased porosity).
  • PLA microparticles facilitated sustained release of C-phycocyanin for up to 48 hours.

Conclusions:

  • Composite hydrogels incorporating porous PLA microparticles exhibit tunable mechanical properties suitable for mimicking connective and cartilage tissues.
  • These hydrogels offer a promising platform for regenerative medicine applications due to their biomimetic structure and controlled release capabilities.
  • The developed hydrogels demonstrate potential for applications requiring enhanced biomechanical performance and localized delivery of therapeutic agents.