Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pedigree Analysis

Pedigree Analysis

Incomplete Dominance

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prevalence and Grade of Patellar Luxation in Cavalier King Charles Spaniels Attending Primary-Care Veterinary Practices in Australia.

Veterinary medicine and science·2026

Same author

Proteomic Signatures of Adiposomes Track Cardiometabolic Risk Reduction Following Bariatric Surgery.

International journal of molecular sciences·2026

Same author

Pyrexia in juvenile dogs: a retrospective analysis of diagnosis and clinical features of 115 Australian cases.

Australian veterinary journal·2026

Same author

A catalogue of early diverged contemporary human genome variation reveals distinct Khoe-San populations.

Nature communications·2026

Same author

Rescue Protocols for Canine Non-Indolent B Cell Lymphoma: A Systematic Review.

Veterinary and comparative oncology·2026

Same author

Genomic and morphometric evidence for Austronesian-mediated pig translocation in the Pacific.

Science (New York, N.Y.)·2026

Search research articles

Related Experiment Video

Updated: Jun 19, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

Genomic Analysis of Lymphoma Risk in Bullmastiff Dogs.

Sally A Mortlock¹, Monica C Asada¹, Pamela Xing Yi Soh^2,3

¹Sydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camperdown, NSW 2006, Australia.

Veterinary Sciences

|December 22, 2023

Summary

This study identified specific genetic regions on chromosomes 13 and 33 that increase lymphoma risk in Bullmastiffs. These findings shed light on the genetic basis of this common canine cancer.

Keywords:

Bullmastiff GWAS canine lymphoma

More Related Videos

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Related Experiment Videos

Last Updated: Jun 19, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients

Published on: June 16, 2017

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Area of Science:

Veterinary Genetics
Canine Oncology
Comparative Genomics

Background:

Lymphoma is a prevalent hematological malignancy in dogs, with a notably high incidence in the Bullmastiff breed.
Understanding the genetic underpinnings of lymphoma predisposition is crucial for targeted interventions and breed-specific health management.

Purpose of the Study:

To pinpoint specific genetic loci associated with lymphoma risk in Bullmastiffs.
To investigate the genomic architecture contributing to lymphoma susceptibility in this breed.

Main Methods:

Genome-wide association analysis (GWAS) was performed comparing genotyped Bullmastiffs with lymphoma (n=49) against a control group (n=281).
Fine-mapping techniques were employed to narrow down associated regions on canine chromosomes (CFA) 13 and 33.
NETVIEW was used to explore fine-scale population structure within the Bullmastiff pedigree.

Main Results:

Genome-wide association analysis identified significant risk regions for lymphoma on CFA13 (approximately 1.2 Mb) and CFA33 (approximately 380 Kb).
Key candidate genes within these regions include MYC, PVT1, SENP7, and NFKBIZ, all implicated in cancer pathways and MYC regulation.
Associated genomic signatures suggest a complex genetic background contributing to lymphoma predisposition in Bullmastiffs.

Conclusions:

The identified genetic regions on CFA13 and CFA33 are strongly associated with lymphoma risk in Bullmastiffs.
Candidate genes like MYC and PVT1, along with SENP7 and NFKBIZ, play a role in the predisposition to canine lymphoma.
These findings contribute to understanding the complex genetic architecture of lymphoma in Bullmastiffs and may inform future diagnostic or therapeutic strategies.