Related Experiment Video
Updated: Jul 7, 2025
10:04
Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
18.8K
High Tuberculosis Preventive Treatment Uptake and Completion Rates Using a Person-Centered Approach among
Felisia Felisia1, Rina Triasih1,2, Betty Weri Yolanda Nababan1
1Centre for Tropical Medicine, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University, Sleman 55281, Yogyakarta, Indonesia.
Tropical Medicine and Infectious Disease
|December 22, 2023
Summary
High completion rates for tuberculosis preventive treatment (TPT) were achieved in Indonesia using shorter TPT regimens and person-centered care. This approach improved TPT adherence and outcomes for TB contacts.
Area of Science:
- Public Health
- Infectious Diseases
- Global Health
Background:
- Tuberculosis preventive treatment (TPT) coverage and completion rates in Indonesia are suboptimal.
- Many individuals initiating TPT do not complete the prescribed treatment course.
Purpose of the Study:
- To evaluate the effectiveness of person-centered contact investigation and shorter TPT regimens in improving TPT uptake and completion.
- To assess the impact of dedicated nursing support on TPT adherence and outcomes.
Main Methods:
- A prospective study involving household contacts of bacteriologically confirmed TB cases in Yogyakarta, Indonesia.
- Provision of a 3-month TPT regimen (3RH or 3HP) with intensive weekly/bi-weekly monitoring by a dedicated nurse.
- Utilizing phone support and home visits for adherence and side-effect management.
Main Results:
- Out of 1016 eligible contacts, 772 (78.8%) initiated short-course TPT.
- A high completion rate of 706 (91.5%) was observed among those who started TPT.
- Side effects were reported by 39% of contacts who did not complete TPT.
Conclusions:
- Person-centered care combined with shorter TPT regimens significantly increases TPT uptake and completion rates.
- Effective side-effect monitoring and management are crucial for successful TPT completion.
- This model demonstrates a viable strategy to improve TB prevention in high-burden settings.
Related Concept Videos
01:28Pulmonary Tuberculosis V
180
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
180
01:29Pulmonary Tuberculosis I
244
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
244
01:26Pulmonary Tuberculosis IV
143
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
143
01:28Pulmonary Tuberculosis II
240
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
240
01:31Pulmonary Tuberculosis III
333
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
333
01:25Transmission-based Precautions II: Airborne and Protective Environment
1.3K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.3K