Magnetic resonance coherence pathway unraveling

Efficiently acquiring multi-contrast magnetic resonance imaging data is crucial for patient comfort and clinical throughput. Developing scan acceleration methods tailored for specific applications drastically improves the value of an MRI examination. Here, we propose a novel method to control the aliasing of simultaneously acquired images of multiple spin echo coherence pathways with the goal of producing high quality multi-contrast images from a single acquisition. Modulating the radiofrequency phase of several pulses applied in brief succession also uniquely modulates the phase of spin echo coherence pathways. A method, termed magnetic resonance coherence pathway unraveling (MR-CPU), to control the aliasing of simultaneously acquired coherence pathway images is developed here along with parallel imaging-based reconstruction methods to separate them. MR-CPU was validated in phantom experiments and tested in vivo. High levels of correlation between reference pathway images and MR-CPU-derived coherence pathway images were found from the phantom experiments. Minimal artifacts arising from the separation of the overlapped coherence pathway images were observed in vivo. MR-CPU provides a novel mechanism through which to acquire and separate multiple overlapped coherence pathway images, thus adding to the diagnostic potential of an MRI exam without the penalty of additional scan time.