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Related Concept Videos

Teratogenicity01:07

Teratogenicity

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
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Predicting and preventing stillbirth at term.

Gordon C S Smith1

  • 1Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, CB2 0SW, UK.

Seminars in Perinatology
|December 22, 2023
PubMed
Summary
This summary is machine-generated.

Stillbirth at term is a rare but devastating outcome. "Omic" analyses of maternal blood may identify high-risk pregnancies for targeted early delivery, improving outcomes.

Keywords:
BiomarkersPregnancyScreeningStillbirth

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Area of Science:

  • Reproductive Medicine
  • Genomics
  • Perinatal Health

Background:

  • Stillbirth affects approximately 1 in 1000 term pregnancies in high-income countries.
  • Maternal characteristics are linked to stillbirth risk, but most at-risk women do not experience stillbirth without intervention.
  • The causes of term stillbirth are often unknown, with multiple contributing pathways like fetal growth restriction or overgrowth.

Purpose of the Study:

  • To explore the potential of "omic" analyses for identifying pregnancies at high risk of stillbirth.
  • To provide a rationale for screening to enable targeted early delivery.

Main Methods:

  • Analysis of maternal blood samples using "omic" techniques.
  • Focus on identifying biomarkers associated with conditions leading to stillbirth.

Main Results:

  • "Omic" analyses show promise in identifying women at high risk for stillbirth.
  • Potential to differentiate pregnancies that would benefit from early delivery.

Conclusions:

  • Early identification of high-risk pregnancies through "omic" screening is feasible.
  • Targeted medically indicated early term delivery can be offered to pregnancies most likely to benefit, potentially reducing stillbirth rates.