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Cosmosiin Induces Apoptosis in Colorectal Cancer by Inhibiting PD-L1 Expression and Inducing ROS.

Jung Ho Han1, Eun-Ji Lee1, Wonyoung Park2

  • 1Korean Medicine (KM)-Application Center, Korea Institute of Oriental Medicine (KIOM), Daegu 41062, Republic of Korea.

Antioxidants (Basel, Switzerland)
|December 23, 2023
PubMed
Summary
This summary is machine-generated.

Cosmosiin, a natural compound, shows promise in colorectal cancer treatment by suppressing PD-L1 expression and inducing cancer cell death. This suggests its potential as a novel immune checkpoint inhibitor for this widespread malignancy.

Keywords:
PD-L1apoptosiscancercosmosiinoxidative stressreactive oxygen species

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Area of Science:

  • Oncology
  • Immunology
  • Natural Products Chemistry

Background:

  • Immune checkpoint inhibitors have revolutionized cancer therapy.
  • Programmed death-ligand 1 (PD-L1) is a critical target in cancer immunotherapy.
  • Colorectal cancer (CRC) is a prevalent malignancy with significant unmet therapeutic needs.

Purpose of the Study:

  • To investigate the therapeutic potential of cosmosiin in colorectal cancer.
  • To determine the effects of cosmosiin on PD-L1 expression in CRC cells.
  • To elucidate the mechanisms underlying cosmosiin's anti-cancer effects.

Main Methods:

  • Treatment of colorectal cancer cell lines with cosmosiin.
  • Assessment of PD-L1 expression levels.
  • Analysis of apoptosis induction and reactive oxygen species (ROS) pathways.

Main Results:

  • Cosmosiin significantly suppressed PD-L1 expression in CRC cells.
  • Cosmosiin treatment triggered apoptosis in colorectal cancer cells.
  • The observed effects were mediated through reactive oxygen species-related pathways.

Conclusions:

  • Cosmosiin demonstrates potent anti-cancer properties against colorectal cancer.
  • Cosmosiin acts by downregulating PD-L1 and inducing apoptosis.
  • Cosmosiin is a promising candidate for development as an immune checkpoint inhibitor for CRC treatment.