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Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
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Nanoparticles and Their Antibacterial Application in Endodontics
Nicoletta Capuano1, Alessandra Amato2, Federica Dell'Annunziata1,3
1Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Antibiotics (Basel, Switzerland)
|December 23, 2023
Summary
Nanoparticles offer a novel solution for root canal treatment, effectively combating persistent bacterial biofilms. This review explores various nanoparticles for endodontic therapy, promising improved outcomes and overcoming antibiotic resistance.
Area of Science:
- Biomedical Engineering
- Materials Science
- Microbiology
Background:
- Root canal treatment faces challenges in eliminating persistent bacterial biofilms with current methods.
- Nanotechnology offers nanoparticles with antimicrobial properties for biomedical applications.
- Nanoparticles disrupt bacterial cell walls, membranes, and DNA replication.
Purpose of the Study:
- To review the application of various nanoparticles in endodontic therapy.
- To highlight the potential of nanoparticles in overcoming limitations of conventional treatments.
- To assess the antimicrobial mechanisms and clinical safety of nanoparticles in endodontics.
Main Methods:
- Literature review of nanoparticles used in endodontic therapy.
- Analysis of antimicrobial mechanisms of nanoparticles.
- Evaluation of clinical safety and applications of nanoparticles.
Main Results:
- Various nanoparticles like chitosan, silver, and graphene show promise in endodontic treatment.
- Nanoparticles exhibit diverse antimicrobial mechanisms, including ion release and reactive oxygen species generation.
- High clinical safety and efficacy suggest nanoparticles can overcome antibiotic resistance and biofilm eradication challenges.
Conclusions:
- Nanoparticles represent a revolutionary approach to endodontic therapy.
- Their broad-spectrum antimicrobial activity and safety profile support their adoption.
- Nanoparticles offer a promising strategy for improved endodontic treatment outcomes and prognosis.
