Related Experiment Video

Updated: Jul 25, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.5K

Association of the BDNF rs6265 Polymorphism with Cognitive Impairment in Multiple Sclerosis: A Case-Control Study in

Adriana Aguayo-Arelis1, Brenda Viridiana Rabago-Barajas1, Ana Miriam Saldaña-Cruz2

  • 1Departamento de Psicología Aplicada, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Ameca 46600, Mexico.

Genes
|December 23, 2023
PubMed

Insights

The brain-derived neurotrophic factor (BDNF) gene rs6265 polymorphism is associated with cognitive impairment in Mexican patients with multiple sclerosis (MS). This genetic variant increases the likelihood of developing cognitive deficits in individuals with MS.

Area of Science:

  • Neuroscience
  • Genetics
  • Neurology

Background:

  • Cognitive impairment (CI) affects 40-60% of multiple sclerosis (MS) patients, often linked to genetic factors.
  • The brain-derived neurotrophic factor (BDNF) gene is implicated in cognitive functions and neuronal plasticity.
  • Genetic variations, such as the BDNF rs6265 polymorphism, may influence susceptibility to CI in MS.

Purpose of the Study:

  • To investigate the association between the BDNF gene rs6265 polymorphism and cognitive impairment in Mexican Mestizo-MS patients.
  • To compare the frequency of BDNF rs6265 genotypes in MS patients with and without cognitive impairment.

Main Methods:

  • A case-control study involving 62 Mexican Mestizo-MS patients (31 cases with CI, 31 controls without CI).
  • Cognitive function assessed using the neuropsychological screening battery for MS (NSB-MS).
  • Genotyping of the BDNF rs6265 polymorphism performed via quantitative real-time PCR (qPCR) using TaqMan probes.

Main Results:

  • No significant differences in sociodemographic or disease variables between case and control groups.
  • Genotype distribution: 68% Val/Val, 29% Val/Met, 3% Met/Met.
  • The BDNF rs6265 polymorphism was associated with a 3.6-fold increased probability of global cognitive impairment in MS patients.

Conclusions:

  • The BDNF gene rs6265 polymorphism is a potential genetic risk factor for cognitive impairment in Mexican Mestizo-MS patients.
  • This finding highlights the role of specific genetic variants in the development of neurological deficits in multiple sclerosis.
  • Further research is warranted to explore the functional mechanisms underlying this association.
Keywords:
BDNFcognitive impairmentmultiple sclerosispolymorphism

More Related Videos

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

3.4K
Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B11:44

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

2.5K

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...