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Mu-Opioid Receptor 1 and C-Reactive Protein Single Nucleotide Polymorphisms as Biomarkers of Pain Intensity and

Aleksander Turczynowicz1, Piotr Jakubów1, Karolina Niedźwiecka2

  • 1Department of Anesthesiology and Intensive Care for Children and Adolescents with Postoperative and Pain Treatment Unit, Medical University of Bialystok, 15-274 Bialystok, Poland.

Brain Sciences
|December 23, 2023
PubMed

Insights

This study investigated single nucleotide polymorphisms (SNPs) in pediatric pain management. While some OPRM1 gene variations suggested a need for coanalgesics, overall, SNPs did not significantly impact postoperative pain control in children.

Area of Science:

  • Pharmacogenomics
  • Pediatric Pain Management
  • Genetics

Background:

  • Children require specialized pain therapy.
  • Single nucleotide polymorphisms (SNPs) in the mu-opioid receptor 1 (OPRM1) gene and rs1205 CRP are linked to pain perception and opioid needs.
  • Understanding genetic influences is crucial for optimizing pediatric pain management.

Purpose of the Study:

  • To investigate the association between OPRM1 and rs1205 CRP SNPs and postoperative pain intensity.
  • To determine the relationship between these SNPs and opioid requirements after scoliosis correction in pediatric patients.
  • To explore correlations with other clinical factors like coanalgesic use and PACU stay.

Main Methods:

  • Genotyping of OPRM1 and rs1205 CRP polymorphisms in 31 pediatric patients.
  • Statistical analysis of genotype frequencies, pain scores, opioid dosage, and clinical outcomes.
  • Comparison of genotype frequencies with European population data (1000Genomes).

Main Results:

  • OPRM1 A/A and A/G genotype frequencies aligned with European population data.
  • Patients with the OPRM1 AG genotype showed a trend towards requiring coanalgesics, but this was not statistically significant.
  • No significant statistical associations were found between OPRM1/CRP polymorphisms and other measured clinical parameters.

Conclusions:

  • This study did not confirm a significant effect of OPRM1 and CRP SNPs on postoperative pain management and opioid therapy in children.
  • Further research with larger sample sizes and additional opioid-related SNPs is warranted.
  • Individualized pain management strategies considering genetic factors may require more extensive investigation.

Keywords:
SNPacute painoprm1postoperative painsingle nucleotide polymorphism

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