Related Experiment Video
Updated: Jul 7, 2025
11:02
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
542
Metabolomics, Lipidomics, and Antipsychotics: A Systematic Review
Kyle J Burghardt1, Megan Kajy1, Kristen M Ward2
1Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University Detroit, Detroit, MI 48201, USA.
Biomedicines
|December 23, 2023
Summary
Metabolomics research reveals consistent changes in metabolites like phosphatidylcholines and carboxylic acids with antipsychotic use. Further controlled studies are needed to validate these biomarkers for personalized psychiatric treatment.
Area of Science:
- Biochemistry
- Pharmacology
- Genomics
Background:
- Antipsychotics are crucial for mental illness treatment, but patient response varies significantly.
- Current selection relies on trial-and-error due to limited understanding of individual efficacy and tolerability.
- Metabolomics offers potential for identifying biomarkers of antipsychotic response.
Purpose of the Study:
- To systematically review metabolites and metabolomic pathways linked to antipsychotic use in humans.
- To identify potential biomarkers for predicting medication effectiveness and toxicity.
Main Methods:
- Systematic review of 42 human studies on metabolomics and antipsychotics.
- Analysis focused on blood-based biosamples (plasma/serum).
- Assessment of 14 metabolite and 12 lipid classes across diverse study designs.
Main Results:
- Consistent perturbations observed: increased phosphatidylcholines, decreased carboxylic acids, and decreased acylcarnitines with antipsychotic exposure.
- Seven metabolites and three lipid species showed replicated findings in targeted studies.
- A decrease in aspartate was the most consistent finding in targeted metabolomic studies.
Conclusions:
- Metabolomic studies on antipsychotics provide a foundation but require more standardized reporting for meta-analysis.
- Validated biomarkers could enable personalized medicine approaches in psychiatry.
- Future research necessitates controlled designs to minimize confounders and maximize metabolomics' potential.
Related Concept Videos
01:28Psychosis and Antipsychotic Drugs: Overview
280
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
280
01:23Antidepressant Drugs: MAOIs and Other Agents
241
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
241
01:24Mania and Antimanic Drugs: Overview
190
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
190
01:26Psychosis: Goals of Pharmacotherapy
141
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
141
01:28Drug Therapy
45
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
45
01:24Overview of Lipid Metabolism
1.6K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
1.6K