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Anti-SARS-CoV-2 Antibody Testing: Role and Indications
Sylvia Mink1,2, Peter Fraunberger1,2
1Central Medical Laboratories, 6800 Feldkirch, Austria.
Journal of Clinical Medicine
|December 23, 2023
Summary
Measuring anti-SARS-CoV-2 antibodies is crucial for vulnerable populations. Antibody levels can guide personalized COVID-19 booster vaccination strategies to improve protection.
Area of Science:
- Immunology
- Infectious Diseases
- Public Health
Background:
- Over 769 million COVID-19 cases and 7 million deaths reported globally.
- Vulnerable groups like older adults and immunocompromised patients remain at high risk.
- Global vaccination efforts have administered over 13.5 billion doses.
Purpose of the Study:
- Evaluate the clinical role of anti-SARS-CoV-2 antibodies.
- Determine indications for antibody measurement.
- Assess prognostic value and role as a correlate of protection.
Main Methods:
- Review of clinical studies on anti-SARS-CoV-2 antibody responses.
- Analysis of antibody measurement indications and prognostic value.
- Evaluation of antibodies as correlates of protection for vaccination strategies.
Main Results:
- Inadequate immune responses to COVID-19 vaccination occur in certain patient subsets.
- Immune responses can decrease with age, impacting vaccine effectiveness.
- Standard booster recommendations may not suffice for all vulnerable individuals.
Conclusions:
- Anti-SARS-CoV-2 antibody measurement is vital for vulnerable patients.
- Antibody levels can inform personalized booster vaccination timing.
- This approach can optimize protection against COVID-19 in high-risk groups.
