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Updated: Jul 7, 2025

Generation of Recombinant Human IgG Monoclonal Antibodies from Immortalized Sorted B Cells
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The Research Progress on Immortalization of Human B Cells

Huiting Xu1, Xinxin Xiang2,3, Weizhe Ding2,4

  • 1Pediatric Department, Nanxiang Branch of Ruijin Hospital, Jiading District, Shanghai 201802, China.

Microorganisms
|December 23, 2023
PubMed
Summary

Human B cell immortalization is crucial for developing antibody drugs and diagnostics. This review covers methods like EBV transformation and CD40 activation for producing therapeutic monoclonal antibodies (mAbs).

Keywords:
EBVSV40genetic modificationhuman B cellmonoclonal antibodies

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