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Probiotics in Postoperative Pain Management.

Barbara Fyntanidou1, Aikaterini Amaniti2, Eleftheria Soulioti3

  • 1Department of Emergency Medicine, Aristotle University of Thessaloniki, 54636 Thessaloniki, Greece.

Journal of Personalized Medicine
|December 23, 2023
PubMed
Summary

Postoperative pain is influenced by gut microbiome changes after surgery. Supplementing with specific probiotic strains may help alleviate this pain through unique mechanisms.

Keywords:
abdominal wall paincannabinoidsinflammationmicrobiomeopioidspostoperative painprobioticsvisceral pain

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Area of Science:

  • Gastroenterology
  • Pain Management
  • Microbiology

Background:

  • Postoperative pain arises from surgical trauma and visceral nociceptor activation.
  • Gut microbiome is significantly altered by anesthesia and surgical procedures.
  • The gut microbiome plays a crucial role in pain perception.

Purpose of the Study:

  • To analyze current knowledge on the relationship between gut microbiome and postoperative pain.
  • To evaluate the potential of probiotics in managing postoperative pain.
  • To understand the strain-specific effects of probiotics on pain relief.

Main Methods:

  • Review of experimental research on gut microbiome and pain.
  • Analysis of studies investigating probiotic interventions post-surgery.
  • Focus on mechanisms of action for different probiotic strains.

Main Results:

  • Anesthesia and surgery disrupt the gut microbiome.
  • Probiotic supplementation shows promise in restoring gut balance.
  • Evidence suggests varied mechanisms of pain relief among different probiotic strains.

Conclusions:

  • Restoring the disturbed gut microbiome with probiotics is a viable strategy for postoperative pain management.
  • Each probiotic strain exerts unique effects on pain relief.
  • Further research into strain-specific efficacy is warranted.