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Hepatitis B Virus and microRNAs: A Bioinformatics Approach
Verdiana Zulian1, Giulia Fiscon2,3, Paola Paci2,3
1Virology Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" IRCCS, 00149 Rome, Italy.
International Journal of Molecular Sciences
|December 23, 2023
Summary
Viral microRNAs (miRNAs) from hepatitis B virus (HBV) impact host gene expression, influencing disease progression. Bioinformatics tools are crucial for analyzing these complex viral-host interactions and developing diagnostic biomarkers.
Area of Science:
- Molecular Biology
- Virology
- Bioinformatics
Background:
- MicroRNAs (miRNAs) are key gene expression regulators.
- Viral miRNAs (v-miRNAs), including those from hepatitis B virus (HBV), play significant roles in infection.
- HBV infection can lead to chronic hepatitis B (CHB), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC).
Purpose of the Study:
- To review bioinformatics tools for viral and host miRNA research.
- To provide an overview of miRNA roles in HBV infection.
- To guide the selection of appropriate bioinformatics tools for researchers.
Main Methods:
- Literature review of bioinformatics tools.
- Analysis of existing research on miRNAs in HBV infection.
- Synthesis of information on viral-host miRNA interactions.
Main Results:
- miRNAs regulate host pathways like apoptosis and immune response during HBV infection.
- v-miRNAs and host miRNAs are potential biomarkers for diagnosis and prognosis.
- Bioinformatics is essential for analyzing complex miRNA data and viral-host interplay.
Conclusions:
- Understanding miRNA dynamics in HBV infection is critical for clinical applications.
- Bioinformatics tools facilitate the analysis and interpretation of miRNA data in viral infections.
- This review aids researchers in selecting suitable bioinformatics tools for HBV-related miRNA studies.
