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Related Experiment Video

Updated: Jul 7, 2025

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
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A Multifactorial Case of Stevens-Johnson Syndrome With Atypical Features.

Jennifer M Paterno1, Zach Breslow2, Mufit A Mamo1

  • 1Family Medicine, Hospital Corporation of America (HCA) Florida St. Petersburg Hospital, St. Petersburg, USA.

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|December 25, 2023
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Summary

Stevens-Johnson syndrome (SJS) is a severe skin reaction with diverse causes. This case highlights how comorbidities can complicate SJS diagnosis, emphasizing the need for broad differential diagnoses.

Keywords:
hypercoagulabilitynikolsky signstevens-johnson syndrome (sjs)toxic epidermal necrolysis (ten)vancomycin infusion

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Area of Science:

  • Dermatology
  • Internal Medicine
  • Pharmacology

Background:

  • Stevens-Johnson syndrome (SJS) is a severe mucocutaneous reaction with varied etiologies, including medications and infections like Mycoplasma.
  • Early identification and management are crucial for patient outcomes.

Observation:

  • A 29-year-old female with a history of recurrent cerebrovascular accidents (CVA) presented with chest pain.
  • Empiric vancomycin was initiated for suspected endocarditis.
  • The patient subsequently developed altered mental status, mucositis, and a chest lesion.

Findings:

  • The clinical presentation was initially concerning for vasculitis.
  • Pathological review and treatment response confirmed a diagnosis of Stevens-Johnson syndrome.
  • Multiple comorbidities complicated the initial presentation and diagnostic process.

Implications:

  • This case underscores the importance of considering SJS in patients with complex medical histories and atypical presentations.
  • Recognizing the diverse risk factors and varied symptoms of SJS is vital for timely diagnosis.
  • Awareness of drug-induced SJS is critical, especially when initiating new medications in patients with comorbidities.