Patency of Drug-Coated versus Conventional Balloon Angioplasty for Hemodialysis Access Stenosis

Thanawat Anukanchanavera1, Keerati Hongsakul1, Phurich Janjindamai1

  • 1Prince of Songkla University, Thailand.

Insights

Drug-coated balloon angioplasty (DCBA) demonstrates superior post-intervention target primary patency compared to conventional balloon angioplasty (CBA) for treating dysfunctional arteriovenous fistulas (AVF). This real-world study confirms DCBA as a beneficial option for maintaining fistula patency in hemodialysis patients.

Area of Science:

  • Vascular Surgery
  • Interventional Nephrology
  • Biomedical Engineering

Background:

  • Dysfunctional autogenous arteriovenous fistulas (AVFs) are a significant challenge in hemodialysis access.
  • Maintaining AVF patency is crucial for effective renal replacement therapy.
  • Endovascular treatments, including conventional balloon angioplasty (CBA) and drug-coated balloon angioplasty (DCBA), are employed to manage AVF dysfunction.

Purpose of the Study:

  • To compare the post-intervention target primary patency of DCBA versus CBA in real-world treatment of dysfunctional autogenous AVFs.
  • To evaluate the effectiveness of DCBA in improving long-term fistula function.

Main Methods:

  • A retrospective study of 24 patients with end-stage renal disease and dysfunctional AVFs undergoing endovascular treatment.
  • Analysis of demographic data, fistula details, and post-intervention target primary patency.
  • Statistical analysis using Weibull proportional hazards regression model.

Main Results:

  • DCBA was identified as a protective factor for treating dysfunctional AVF lesions (adjusted hazard ratio: 0.725, P=0.047).
  • DCBA demonstrated significantly longer post-intervention target primary patency compared to CBA.
  • The study included 333 endovascular treatments across 57 target lesions in 16 men and 8 women.

Conclusions:

  • DCBA offers superior post-intervention target primary patency for dysfunctional autogenous AVFs in a real-world clinical setting.
  • DCBA represents an effective treatment option for improving and maintaining AVF function in hemodialysis patients.
Abstract

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