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Patency of Drug-Coated versus Conventional Balloon Angioplasty for Hemodialysis Access Stenosis
Thanawat Anukanchanavera1, Keerati Hongsakul1, Phurich Janjindamai1
1Prince of Songkla University, Thailand.
Insights
Drug-coated balloon angioplasty (DCBA) demonstrates superior post-intervention target primary patency compared to conventional balloon angioplasty (CBA) for treating dysfunctional arteriovenous fistulas (AVF). This real-world study confirms DCBA as a beneficial option for maintaining fistula patency in hemodialysis patients.
Area of Science:
- Vascular Surgery
- Interventional Nephrology
- Biomedical Engineering
Background:
- Dysfunctional autogenous arteriovenous fistulas (AVFs) are a significant challenge in hemodialysis access.
- Maintaining AVF patency is crucial for effective renal replacement therapy.
- Endovascular treatments, including conventional balloon angioplasty (CBA) and drug-coated balloon angioplasty (DCBA), are employed to manage AVF dysfunction.
Purpose of the Study:
- To compare the post-intervention target primary patency of DCBA versus CBA in real-world treatment of dysfunctional autogenous AVFs.
- To evaluate the effectiveness of DCBA in improving long-term fistula function.
Main Methods:
- A retrospective study of 24 patients with end-stage renal disease and dysfunctional AVFs undergoing endovascular treatment.
- Analysis of demographic data, fistula details, and post-intervention target primary patency.
- Statistical analysis using Weibull proportional hazards regression model.
Main Results:
- DCBA was identified as a protective factor for treating dysfunctional AVF lesions (adjusted hazard ratio: 0.725, P=0.047).
- DCBA demonstrated significantly longer post-intervention target primary patency compared to CBA.
- The study included 333 endovascular treatments across 57 target lesions in 16 men and 8 women.
Conclusions:
- DCBA offers superior post-intervention target primary patency for dysfunctional autogenous AVFs in a real-world clinical setting.
- DCBA represents an effective treatment option for improving and maintaining AVF function in hemodialysis patients.
Purpose:
This study aimed to evaluate the post-intervention target primary patency of drug-coated balloon angioplasty (DCBA) compared with conventional balloon angioplasty (CBA) in the treatment of the dysfunctional autogenous arteriovenous fistula (AVF) in a real-world clinical setting.
Materials And Methods:
This retrospective study included 24 patients with end-stage renal disease, who developed dysfunctional AVF during hemodialysis, and underwent endovascular treatment using CBA and DCBA from January 1, 2014, to June 30, 2021. The demographic data of patients and details regarding their fistula were recorded. Post-intervention target primary patency was analyzed.
Results:
Sixteen men and 8 women with an average age of 63.9 ± 14.2 years, who underwent 333 endovascular treatments in 57 target lesions of access were enrolled. DCBA was a protective factor for the treatment of a target lesion of dysfunctional access with an adjusted hazard ratio of 0.725 (95% confidence interval [CI]: 0.528-0.996; P = 0.047). According to the Weibull proportional hazards regression model, DCBA showed a longer post-intervention target primary patency than CBA.
Conclusion:
DCBA has better outcomes in terms of post-intervention target primary patency in the real-world treatment of dysfunctional autogenous AVF.
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