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Related Experiment Video

Updated: Jul 7, 2025

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Viability of Bioprinted Cellular Constructs Using a Three Dispenser Cartesian Printer

Published on: September 22, 2015

Diffusion-Based 3D Bioprinting Strategies.

Betty Cai¹, David Kilian¹, Daniel Ramos Mejia¹

¹Department of Materials Science and Engineering, Stanford University, 476 Lomita Mall, Stanford, CA, 94305, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|December 25, 2023

Summary

This summary is machine-generated.

Controlled diffusion is a key strategy in 3D bioprinting for tailoring tissue constructs. This approach manipulates molecular movement to precisely control material properties and cell behavior in biofabrication.

Keywords:

bioprinting diffusion interfacial gelation multi-material constructs perfusable structures

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Published on: July 2, 2018

Area of Science:

Biomaterials Engineering
Tissue Engineering
Biotechnology

Background:

3D bioprinting allows fabrication of cell-laden, tissue-mimetic constructs with complex geometries.
Controlled diffusion is an emerging strategy to precisely engineer bioprinted construct properties.
Molecular diffusion influences microstructure, stiffness, and biochemistry, impacting cell phenotype.

Purpose of the Study:

To review recent advances in diffusion-based 3D bioprinting strategies.
To discuss methods for characterizing and predicting diffusion in bioprinting.
To highlight future directions for overcoming biofabrication limitations using diffusion.

Main Methods:

Categorization of diffusion-based strategies: inward, outward, and internal diffusion.
Review of applications including diffusion-induced gelation for multi-material constructs.
Discussion of characterization and prediction methods for diffusion processes.

Main Results:

Diffusion strategies enable tailoring of construct properties like stiffness and microstructure.
Inward, outward, and internal diffusion offer distinct control mechanisms.
Diffusion-induced gelation facilitates creation of complex geometries and dynamic properties.

Conclusions:

Diffusion-based strategies are crucial for advanced biofabrication.
Further research in diffusion characterization and prediction is needed.
Optimizing diffusion control will enhance capabilities in tissue engineering and regenerative medicine.