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Related Experiment Video

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Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
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QUANTITATIVE AUTOFLUORESCENCE IN CENTRAL SEROUS CHORIORETINOPATHY.

Constance Weber1, Lea Sophie Schaetzle, Isabel Stasik

  • 1Department of Ophthalmology, University of Bonn, Germany.

Retina (Philadelphia, Pa.)
|December 26, 2023
PubMed
Summary

Quantitative autofluorescence (qAF) is elevated in both eyes of central serous chorioretinopathy (CSC) patients compared to healthy individuals. This suggests qAF alterations may precede clinical CSC diagnosis.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Retinal Diseases

Background:

  • Central serous chorioretinopathy (CSC) is linked to pachychoroid and retinal pigment epithelium dysfunction.
  • Altered autofluorescence (AF) is a known characteristic of CSC.
  • Quantitative AF (qAF) offers a method to measure these alterations.

Purpose of the Study:

  • To quantify autofluorescence alterations in patients with CSC.
  • To compare qAF in CSC-affected eyes, fellow eyes, and healthy controls.
  • To investigate if qAF changes are present before clinical manifestation of CSC.

Main Methods:

  • Prospective recruitment of CSC patients and healthy controls.
  • Clinical examination including visual acuity and optical coherence tomography.
  • Quantitative autofluorescence (qAF) imaging using a confocal scanning laser ophthalmoscope.
  • Assessment of qAF values in specific regions (Delori grid).

Main Results:

  • 141 eyes from 77 CSC patients and 39 healthy eyes were analyzed.
  • No significant qAF difference was found between CSC-affected eyes and asymptomatic fellow eyes.
  • Both CSC-affected and fellow eyes showed significantly higher qAF values compared to healthy controls.

Conclusions:

  • Patients with CSC exhibit increased qAF in both affected and unaffected eyes.
  • These qAF alterations suggest subclinical changes may occur before visible signs of CSC.
  • qAF may serve as an early indicator for CSC development or progression.