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Association of Geriatric Nutritional Risk Index With Adverse Event and Treatment Duration in Adjuvant Chemotherapy

Atsuya Shimizu¹, Miyu Fukasawa², Ryosuke Endo¹

¹Department of Pharmacy, JR Sapporo Hospital, Sapporo, Japan.

In Vivo (Athens, Greece)

|December 26, 2023

Abstract

Background/Aim:

In recent years, the Geriatric Nutritional Risk Index (GNRI) has been reported as a predictor of prognosis in many patients with cancer. This study investigated the association of preoperative GNRI with the occurrence of adverse events and duration of treatment with capecitabine plus oxaliplatin (CAPOX), a postoperative adjuvant chemotherapy, in 59 patients with colorectal cancer from September 2019 to April 2022.

Patients And Methods:

A cut-off value of 100.9 was used to categorize patients into high and low GNRI groups.

Results:

The incidence of grade ≥2 leukopenia (p=0.03), and all grades peripheral neuropathy (p=0.04) were significantly more frequent in the low GNRI group. Analysis of factors influencing treatment duration by univariate and multivariate Cox regression proportional hazards models showed a significant difference in GNRI (p=0.0097).

Conclusion:

GNRI, a nutritional indicator assessed before the start of treatment, influences the occurrence of adverse events and duration of treatment with CAPOX as adjuvant chemotherapy. To complete CAPOX therapy, preoperatively, it is important to assess the patients' nutritional status using the GNRI and to actively intervene in nutritional therapy.

Keywords:

GNRI adjuvant chemotherapy adverse events colorectal cancer duration of treatment

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