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Updated: Jul 7, 2025

Synthesis and Reaction Chemistry of Nanosize Monosodium Titanate
Published on: February 23, 2016
Visible-Light-Promoted Reduction of Epoxides, Hydroxysulfonates, and Halohydrines with Alkyltitanium Alkoxides
Artyom Mikhaliov1, Aliaksei Flerko2, Dziyana Atroshchanka1
1Republican Scientific Center of Human Issues, Belarusian State University, Kurčatava 7, Minsk 220064, Belarus.
Abstract:
Alkyltitanium alkoxides generally serve as nucleophiles in reactions with carbonyl compounds and cross-coupling. Their application as reductants is known but remains underdeveloped. Here, we report that irradiation with visible light makes these organometallic compounds efficient reducing agents for the dehalogenation of 1,2- and 1,3-haloalcohols. This reaction was utilized for the reduction of epoxides and sulfonates, which proceeded through a sequence of the in situ halohydrin formation and photochemical dehalogenation. Ester, amide, nitrile, alkyne, and remote bromide groups were stable under the reaction conditions.
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