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Related Concept Videos

Infection01:20

Infection

8.0K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.0K
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

2.1K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.1K
Pneumonia IV: Management01:28

Pneumonia IV: Management

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The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
331
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

1.3K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.3K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

279
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
279
Methods of Documentation II: POMR01:26

Methods of Documentation II: POMR

957
The Problem-Oriented Medical Record (POMR) revolutionized medical record-keeping by introducing a systematic approach focusing on the patient's problems rather than merely listing symptoms. Dr. Lawrence Weed's introduction of this method in the 1960s marked a significant advancement in medical documentation. The POMR framework consists of four key components: the database, problem list, plan of care, and progress notes.
957

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Updated: Jul 7, 2025

Vaccinia Reporter Viruses for Quantifying Viral Function at All Stages of Gene Expression
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Vaccinia Reporter Viruses for Quantifying Viral Function at All Stages of Gene Expression

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Mpox (formerly monkeypox): pathogenesis, prevention, and treatment.

Junjie Lu1, Hui Xing1, Chunhua Wang1

  • 1Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei Province, Xiangyang, 441021, China.

Signal Transduction and Targeted Therapy
|December 26, 2023
PubMed
Summary
This summary is machine-generated.

The 2022 Mpox outbreak highlights limited treatment options and the urgent need for new antiviral drugs. This review summarizes current Mpox pathophysiology, approved treatments, and emerging drug development strategies.

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Area of Science:

  • Virology
  • Infectious Diseases
  • Pharmacology

Background:

  • The 2022 global Mpox (formerly monkeypox) outbreak necessitated urgent research into effective treatments.
  • Limited approved antiviral therapies and emerging drug resistance underscore the need for novel interventions.
  • The Mpox virus's high mutability poses challenges for existing treatments and bioterrorism concerns.

Purpose of the Study:

  • To provide a comprehensive review of Mpox pathophysiology and current treatment strategies.
  • To summarize the latest advancements in anti-Mpox drug development.
  • To offer insights into drug repurposing, AI-driven target discovery, and preclinical development for Mpox.

Main Methods:

  • Literature review of physiological and pathological processes of Mpox infection.
  • Analysis of approved anti-Mpox drugs and newly identified antiviral compounds.
  • Exploration of drug development strategies, including drug repurposing and AI-driven discovery.

Main Results:

  • Limited therapeutic options are currently available for Mpox virus infection.
  • Several small-molecule compounds and antibody drugs show potential antiviral efficacy.
  • Drug resistance and bioterrorism threats necessitate the development of novel antiviral drugs.

Conclusions:

  • There is a critical need for novel antiviral drugs to combat Mpox, addressing both drug resistance and potential bioterrorism threats.
  • This review consolidates current knowledge on Mpox pathophysiology and drug development, aiding future research and clinical application.
  • Insights from drug repurposing and AI-driven discovery offer promising avenues for accelerated Mpox therapeutic development.