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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Updated: Jul 7, 2025

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Current surgical management for melanoma.

Shigeru Koizumi^1,2, Takashi Inozume², Yasuhiro Nakamura¹

¹Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center, Saitama, Japan.

The Journal of Dermatology

|December 27, 2023

Summary

This summary is machine-generated.

Melanoma treatment advances with new drugs, reducing the need for extensive surgery. However, surgery remains crucial for early-stage melanoma, staging, and palliative care in advanced cases.

Keywords:

malignant melanoma neoadjuvant therapy regional lymph node dissection sentinel lymph node biopsy surgery

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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

Area of Science:

Dermatology
Surgical Oncology
Medical Oncology

Background:

Melanoma is a significant skin cancer with high mortality.
Recent advances include immune checkpoint inhibitors and molecular-targeted agents for adjuvant therapy.
Neoadjuvant therapy shows promise, particularly in patients with palpable lymph nodes.

Purpose of the Study:

To re-evaluate the role of surgery in melanoma treatment.
To discuss surgical management in the context of novel drug therapies.
To focus on surgery for primary tumors, lymph nodes, and metastatic sites.

Main Methods:

Review of recent clinical trial data, including a large phase III trial on lymph node dissection.
Analysis of the impact of adjuvant and neoadjuvant therapies on surgical indications.
Discussion of the evolving role of surgery in different melanoma stages.

Main Results:

A large phase III trial found no survival benefit from early lymph node dissection for sentinel lymph node metastases.
Effective adjuvant and neoadjuvant therapies are emerging, potentially reducing the need for invasive surgery.
Surgery's role is shifting, with less emphasis on extensive dissection but continued importance in specific contexts.

Conclusions:

Surgery's role in melanoma management needs reconsideration due to effective systemic therapies.
While less invasive procedures may be favored, surgery remains vital for early-stage diagnosis, staging, and palliative care.
The integration of surgical and systemic treatments is key for optimal melanoma patient outcomes.