Related Experiment Video
Updated: Aug 6, 2026

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Live Imaging of Mitosis in the Developing Mouse Embryonic Cortex
Published on: June 4, 2014
Thalamic and cortical spindles during early ontogenesis in kittens
Brain Research
|January 1, 1987
Abstract:
On birth, focal thalamic recordings show sporadic sequences of spindle waves whereas EEG cortical recordings show no trace of spindles. Thalamic spindles are occasionally transferred to the cortex beginning with the 3rd-4th day. On the 8th-9th day, clear-out spindle sequences, with the same patterns as in the adult animal, appear simultaneously in the thalamus and cortex.
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The Mitotic Spindle
The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures bipolar mitotic...
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures bipolar mitotic...
Spindle Assembly
Spindle assembly occurs through three, often coexisting, pathways – the centrosome-mediated pathway, the chromatin-mediated pathway, and the microtubule-mediated pathway – collectively contributing to form a robust spindle apparatus.
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a microtubule array...
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a microtubule array...

