[Advances in live-imaging aging reporter mice]
Jie Sun1,2, Yu-Ning Wang3, Shan-Shan Luo4
1School of Basic Medical Science, Shenzhen University, Shenzhen 518060, China.
Sheng Li Xue Bao : [Acta Physiologica Sinica]
|December 27, 2023
Summary
Live-imaging reporter mouse models offer new ways to study aging mechanisms. These models, using biomarkers like p16Ink4a, help understand aging and develop interventions for age-related diseases.
Area of Science:
- Gerontology and molecular biology
- Biomedical imaging and mouse models
Background:
- Aging is a primary risk factor for chronic diseases in older adults.
- Understanding aging mechanisms is crucial for disease prevention and intervention.
- The dynamic and systemic nature of aging complicates mechanistic studies.
Conclusions:
- Live-imaging aging reporter mouse models represent a significant advancement in gerontology.
- These models provide powerful tools for investigating aging at a systemic level.
- Their application aids in understanding and potentially mitigating age-related diseases.
