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Acoustofluidics-Assisted Multifunctional Paper-Based Analytical Devices.

Xiong Zhao1,2, Zihan Ding1, Hongqiang Chen1

  • 1School of Chemical Engineering and Technology, Xi'an Jiaotong University, 28 Xianning West Road, Xi'an, Shaanxi 710049, P.R. China.

Analytical Chemistry
|December 28, 2023
PubMed
Summary
This summary is machine-generated.

This study integrates microfluidic paper-based analytical devices with acoustofluidics to create multifunctional platforms. These devices enable uniform colorimetric detection, cell enrichment, fluorescence amplification, and nanomaterial synthesis on paper.

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Area of Science:

  • Microfluidics
  • Analytical Chemistry
  • Acoustics

Background:

  • Microfluidic paper-based analytical devices (μPADs) are economical and sensitive.
  • Acoustofluidics offers contactless and versatile manipulation.
  • Integrating these technologies holds significant potential.

Purpose of the Study:

  • To develop acoustofluidics-assisted multifunctional paper-based analytical devices.
  • To leverage bulk acoustic waves for diverse applications on paper.
  • To overcome limitations of traditional μPADs.

Main Methods:

  • Utilized bulk acoustic waves for manipulation on paper substrates.
  • Demonstrated uniform colorimetric detection (e.g., glucose).
  • Employed acoustofluidics for particle/cell enrichment and fluid mixing.

Main Results:

  • Achieved uniform colorimetric detection of glucose (5-15 mM).
  • Enriched various microparticles and cells (5-200 μm) rapidly.
  • Demonstrated 3x fluorescence amplification, high-throughput mixing, and ZnO nanosheet synthesis.

Conclusions:

  • Acoustofluidics-assisted μPADs enable diverse applications on paper.
  • Mechanisms involve Faraday waves and Chladni patterns.
  • These devices offer simple fabrication and high effectiveness for future applications.