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[Persistent form of bovine viral diarrhea]
A V Mishchenko1, V A Mishchenko1,2, M I Gulyukin1
1Federal Scientific Center VIEV.
Voprosy Virusologii
|December 29, 2023
Summary
Bovine Viral Diarrhea/Mucosal Disease (BVD) persistence in cattle is influenced by virus and host factors, including immune responses. Understanding these elements is key to controlling this economically damaging global disease.
Area of Science:
- Veterinary Virology
- Immunology
- Animal Science
Context:
- Bovine Viral Diarrhea/Mucosal Disease (BVD) is a significant global cattle pathogen causing substantial economic losses in beef and dairy industries.
- BVDV infection leads to diverse clinical manifestations, including gastrointestinal and respiratory damage, reproductive failures, abortions, and stillbirths.
Purpose:
- To review and analyze existing literature on the factors contributing to the persistent form of Bovine Viral Diarrhea/Mucosal Disease (BVD).
- To focus on the interplay between virus-specific elements and host-related factors, particularly immune responses, in establishing BVDV persistence.
Summary:
- The review synthesizes data on viral and host determinants of BVDV persistence.
- Key factors examined include viral characteristics and host immune responses that facilitate chronic infection.
- Persistent BVDV infection poses a continuous threat to cattle health and herd productivity.
Impact:
- Provides a comprehensive overview of BVDV persistence mechanisms for researchers and veterinarians.
- Informs strategies for the control and eradication of BVDV in cattle populations.
- Highlights the importance of host-pathogen interactions in understanding persistent viral infections in livestock.
