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Distinct immunoreactions after a primary tumor microwave ablation using different heating parameters in a VX2 tumor
Mengjia Qian1, Jin Lyu2, Xia Da2
1Department of Thyroid and Breast Surgery, The Affiliated JiangNing Hospital of Nanjing Medical University, Nanjing, People's Republic of China.
Journal of Cancer Research and Therapeutics
|December 29, 2023
Summary
High-power microwave ablation (MWA) effectively activates anti-tumor immunity, increasing T-cells and beneficial cytokines. This suggests high-power MWA is a promising treatment for solid tumors by enhancing immune responses.
Area of Science:
- Immunology
- Oncology
- Medical Devices
Background:
- Thermal ablation, including microwave ablation (MWA), can stimulate anti-tumor immune responses.
- Different MWA energy modes may induce varying local inflammatory effects.
- Understanding these immunological effects is crucial for optimizing tumor treatment.
Purpose of the Study:
- To investigate the immunological effects of different microwave ablation (MWA) energy modes on primary tumors.
- To compare the immune responses induced by high-power MWA, low-power MWA, and surgical resection.
Main Methods:
- Seventy rabbits with VX2 tumors were treated with high-power MWA (40 W, 1 min), low-power MWA (20 W, 2 min), surgical resection, or no treatment.
- Immunohistochemistry and flow cytometry assessed T-cell responses (CD4+, CD8+) on day 14.
- Enzyme-linked immunosorbent assay (ELISA) identified cytokine patterns (IL2, IL12, IL4, IL6, IL10).
Main Results:
- Microwave ablation (MWA) led to complete tumor eradication and improved survival compared to controls.
- MWA induced higher intra-tumoral and systemic CD4+ and CD8+ T-cell responses.
- High-power MWA significantly increased intra-tumoral and systemic T-cells and elevated IL12 levels more than low-power MWA.
Conclusions:
- High-power microwave ablation (MWA) enhances type 1 T helper immune responses.
- MWA demonstrates potential as an immunotherapy for solid tumors.
- Further research is warranted to validate these findings.
