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Novel Gluconobacter oxydans strains selected from Kombucha with potential postbiotic activity
Katarzyna Neffe-Skocińska1, Ewa Długosz2, Lidia Szulc-Dąbrowska2
1Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS), Nowoursynowska St. 159, 02-776, Warsaw, Poland. katarzyna_neffe_skocinska@sggw.edu.pl.
Applied Microbiology and Biotechnology
|December 29, 2023
Summary
Acetic acid bacteria (AAB) from Kombucha, specifically Gluconobacter oxydans, show promising postbiotic potential. These bacteria exhibit anticancer activity, particularly against gastric adenoma cells, suggesting a complementary role in cancer therapy.
Area of Science:
- Microbiology
- Gastroenterology
- Biotechnology
Background:
- Gastric and colorectal cancers are leading causes of cancer diagnoses.
- There is a need for complementary or preventive therapies.
- Postbiotic bacterial metabolites are gaining attention for their health benefits.
Purpose of the Study:
- To assess the safety and functional properties of cell-free metabolites from Gluconobacter oxydans strains.
- To evaluate the antimicrobial and anti-cancer activity of these metabolites.
- To explore the postbiotic potential of acetic acid bacteria (AAB) from Kombucha.
Main Methods:
- Isolation and characterization of five AAB strains from Kombucha.
- Testing of cell-free supernatants against human cell lines (AGS, HT-29, HUVEC).
- Assessment of safety, antimicrobial, and anti-cancer effects.
Main Results:
- Selected AAB strains demonstrated health safety and functional properties.
- The KNS30 strain of Gluconobacter oxydans showed significant anticancer activity against AGS gastric adenoma cells.
- Cell-free supernatants exhibited potential postbiotic properties.
Conclusions:
- Acetic acid bacteria, particularly Gluconobacter oxydans from Kombucha, possess significant postbiotic potential.
- These bacteria and their metabolites show promise as a complementary approach for gastric cancer therapy.
- Further research into AAB applications in health is warranted.
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