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Published on: May 21, 2019
Intramolecular Cobalt/Visible Light Cocatalyzed Reductive Coupling of Unactivated Arenes with Unactivated Alkenes
Jianpeng Cai1,2, Guohui Zeng1,2, Kai Jiang1,2
1School of Chemistry and Chemical Engineering, South China University of Technology, 381 Wushan, Tianhe, Guangzhou 510640, China.
Abstract:
A protocol for the intramolecular reductive coupling of unactivated arenes with unactivated alkenes has been developed with the aid of a cooperative visible light/cobalt catalytic system. This coupling is achieved via radical cascade cyclization using amines as terminal reducing reagents and water as the main hydrogen source. In their form, readily available N-allyl benzamides are converted to the corresponding spiro cyclohexadiene-lactam or β-phenethylamine analogues in moderate to excellent yields.
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