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Published on: May 26, 2023
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Subretinal hyperreflective material in retinal and chorioretinal disorders: A comprehensive review
Alessandro Feo1, Elisa Stradiotto1, Riccardo Sacconi2
1Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milan, Italy.
Survey of Ophthalmology
|December 31, 2023
Summary
Subretinal hyperreflective material (SHRM) is a key optical coherence tomography (OCT) biomarker in various retinal diseases. Its characteristics and significance are increasingly recognized across multiple ocular conditions.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Subretinal hyperreflective material (SHRM) is a notable optical coherence tomography (OCT) finding.
- Its clinical significance is increasingly recognized in various retinal and chorioretinal diseases.
Purpose of the Study:
- To summarize the nature and multimodal imaging characteristics of SHRM.
- To discuss its prognostic and predictive significance in retinal disorders.
Main Methods:
- Review of literature on SHRM in retinal diseases.
- Analysis of multimodal imaging, including OCT angiography.
- Characterization of SHRM components and morphological changes.
Main Results:
- SHRM is a common biomarker in conditions like age-related macular degeneration and central serous chorioretinopathy.
- Multimodal imaging aids in detailed SHRM characterization and post-treatment assessment.
- SHRM's role is significant in understanding disease progression and treatment response.
Conclusions:
- SHRM is a valuable biomarker with emerging clinical utility.
- Further understanding of SHRM aids in managing diverse retinal and choroidal disorders.
- Multimodal imaging enhances the diagnostic and prognostic value of SHRM.

