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Label-free biosensing with singular-phase-enhanced lateral position shift based on atomically thin plasmonic

Shaodi Zhu1,2, Rodolphe Jaffiol1, Aurelian Crunteanu3

  • 1Light, Nanomaterials & Nanotechnologies (L2n), CNRS-EMR 7004, University of Technology of Troyes, 10000, Troyes, France.

Light, Science & Applications
|December 31, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces a novel plasmonic biosensor using a germanium-antimony-tellurium (GST) layer for enhanced sensitivity in disease diagnosis. The new sensor achieves ultra-high sensitivity for detecting trace biomolecules like cancer markers.

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Area of Science:

  • Plasmonics and Nanotechnology
  • Biosensing and Diagnostics
  • Materials Science

Background:

  • Conventional plasmonic sensors require secondary labels for higher sensitivity, limiting their application in early disease diagnosis.
  • Angle-interrogating plasmonic sensors face challenges in achieving high sensitivity without amplification strategies.

Purpose of the Study:

  • To develop a highly sensitive plasmonic biosensor by enhancing the lateral position shift using phase singularity.
  • To utilize a novel germanium-antimony-tellurium (GST) layer as a phase-response-enhancing material for plasmonic sensing.

Main Methods:

  • Fabrication of an atomically thin germanium-antimony-tellurium (GST) layer on a silver nanofilm.
  • Engineering the GST layer to induce phase singularity and enhance the lateral position shift of the reflected beam.
  • Utilizing the enhanced lateral position shift for label-free detection of biomolecules.

Main Results:

  • Achieved a record-breaking lateral position shift of 439.3 μm, demonstrating an ultra-high sensitivity of 1.72 × 108 nm RIU-1.
  • Determined a low detection limit of 6.97 × 10-7 RIU with a figure of merit (FOM) of 4.54 × 1011 μm (RIU∙°)-1.
  • Successfully detected trace amounts of cytokine biomarkers (TNF-α, IL-6) down to 1 × 10-16 M and measured protein-ligand interactions.

Conclusions:

  • The developed plasmonic biosensor with GST exhibits unprecedented sensitivity and a large FOM for label-free detection.
  • This technology enables the detection of critical cancer biomarkers at clinically relevant low concentrations.
  • The sensor demonstrates potential for advancing early disease diagnosis and molecular biology research.