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Related Experiment Video

Updated: Jul 6, 2025

Microdissection of Mouse Brain into Functionally and Anatomically Different Regions
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Rodent brain extraction and dissection: A comprehensive approach.

Refat Aboghazleh1,2, Silvia D Boyajian1, Afnan Atiyat1

  • 1Department of Basic Medical Sciences, Faculty of Medicine, Al-Balqa Applied University, The College of Medicine Building, Al-Salt 19117, Jordan.

Methodsx
|January 1, 2024
PubMed
Summary

This study presents a novel, paraformaldehyde-free method for rodent brain extraction, preserving brain integrity. It offers a detailed guide for dissecting specific brain regions, enhancing precision in neuroscience research.

Keywords:
Brain extraction and dissectionBrain hemispheresIsolation brain regionsRat brain

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Area of Science:

  • Neuroscience
  • Animal research

Background:

  • Neuroscience research relies heavily on animal models like rats and mice.
  • Monitoring cerebral changes requires precise experimental techniques.

Purpose of the Study:

  • To introduce a practical method for rodent brain extraction without paraformaldehyde perfusion.
  • To provide a detailed guide for dissecting key brain regions, ensuring brain integrity and anatomical clarity.

Main Methods:

  • Developed a paraformaldehyde-free brain extraction technique.
  • Created a step-by-step dissection protocol for specific rodent brain regions (hippocampus, cerebral cortex, corpus striatum, thalamus, cerebellum, medial prefrontal cortex).
  • Utilized high-resolution images for anatomical reference.

Main Results:

  • Achieved successful brain extraction without paraformaldehyde.
  • Demonstrated enhanced reliability and precision in dissecting various brain regions.
  • Provided detailed anatomical descriptions and clarity through accompanying images.

Conclusions:

  • A reliable technique for brain extraction without paraformaldehyde perfusion has been established.
  • A comprehensive methodology for dissecting rodent brain regions is now available, supporting neuroscience research.