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Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...

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Related Experiment Video

Updated: Jul 6, 2025

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma

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Published on: February 22, 2015

Neuroblastoma in a Newborn Female.

Leslie Peard¹, Ali Ziada¹, Andrew James¹

¹Department of Urology, University of Kentucky, Lexington, KY.

|January 1, 2024

Summary

Neonatal neuroblastoma, a common infant tumor, can differ from adult forms. This case shows surgical management challenges and emphasizes careful diagnosis for retroperitoneal masses in newborns.

Area of Science:

Pediatric Oncology
Neonatal Medicine
Surgical Management

Background:

Neuroblastoma is the most frequent solid tumor diagnosed in neonates.

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While aggressive in older children, neonatal neuroblastoma often exhibits a less aggressive behavior.

Management strategies for neonatal neuroblastoma vary, with observation sometimes being sufficient.