Protein-based bioactive coatings: from nanoarchitectonics to applications

Area of Science:

• Biomaterials Science
• Surface Chemistry
• Biotechnology

Background:

• Protein-based bioactive coatings are crucial for improving biomedical material performance and biocompatibility.
• Surface modification with these coatings imparts novel biofunctional properties, increasing material bioactivity.
• Their adoption in various biomedical fields highlights their significance.

Purpose of the Study:

• To systematically review the behavior and mechanisms of protein-based bioactive coatings in biological systems.
• To highlight advancements in artificial synthesis methods and in vitro applications.
• To delineate assembly strategies for developing and implementing these coatings.

Main Methods:

• Literature review focusing on protein-based bioactive coatings.
• Analysis of in vivo behavior and mechanisms.
• Evaluation of in vitro functional applications and synthesis methodologies.
• Examination of coating assembly strategies.

Main Results:

• Protein coatings significantly enhance material bioactivity and biocompatibility.
• Artificial synthesis methods offer versatile routes for creating functional coatings.
• Understanding assembly strategies is key to successful coating development and application.
• In vitro studies demonstrate diverse functional applications.

Conclusions:

• Protein-based bioactive coatings represent a versatile strategy for advanced biomedical materials.
• Further research into synthesis and assembly is needed for broader clinical translation.
• Continued exploration of mechanisms and applications will drive innovation in the field.