Oligourea helix bundle binds detergents with diverse polar head groups
Sung Hyun Yoo1,2, Jérémie Buratto1, Arup Roy1
1Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, IECB, 2 rue Robert Escarpit, 33607, Pessac, France. g.guichard@iecb.u-bordeaux.fr.
Organic & Biomolecular Chemistry
|January 3, 2024
Summary
Oligourea foldamers bind diverse detergent molecules, as shown by new crystal structures. This research advances understanding of foldamer-guest interactions and aids in designing new self-assembling materials.
Area of Science:
- Supramolecular Chemistry
- Structural Biology
- Polymer Science
Background:
- Oligourea foldamers are synthetic molecules with potential for self-assembly.
- Understanding how these foldamers interact with small molecules is crucial for their application.
Purpose of the Study:
- To investigate the structural basis of detergent binding to oligourea foldamer helix bundles.
- To provide biophysical data complementing the structural insights.
Main Methods:
- X-ray crystallography was used to determine the structures of foldamer-guest complexes.
- Biophysical techniques were employed to characterize the interactions.
Main Results:
- A series of crystal structures revealed diverse detergent guests bound to an oligourea foldamer helix bundle.
- The data provide detailed structural and chemical information on guest recognition.
Conclusions:
- The findings significantly enhance the understanding of aqueous guest recognition by oligourea foldamers.
- This work will facilitate the design of novel functionalized oligourea-based self-assemblies.
Related Concept Videos
01:18Detergent Purification of Membrane Proteins
5.2K
Detergents are used to purify the integral proteins of the membrane. The hydrophobic portion of the detergent can replace membrane phospholipids while solubilizing the membrane proteins. When detergent monomers reach a specific concentration in a solution called critical micelle concentration (CMC), they form micelles. Above CMC, the concentration of the detergent monomers remains in equilibrium with the micelle. The number of detergent monomers present in the CMC varies for each detergent, and...
5.2K
03:00Solubility
17.5K
Solution, Solubility, and Solubility Equilibrium
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
A solution is a homogeneous mixture composed of a solvent, the major component, and a solute, the minor component. The physical state of a solution—solid, liquid, or gas—is typically the same as that of the solvent. Solute concentrations are often described with qualitative terms such as dilute (of relatively low concentration) and concentrated (of relatively high concentration).
In a solution, the solute particles (molecules,...
17.5K
03:22Colloids
17.5K
Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles that are visible to the naked eye or can be seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. On the other hand, a solution is a homogeneous mixture in which no settling occurs and in which the dissolved...
17.5K
01:03Single-Strand DNA Binding Proteins
14.1K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
14.1K
01:22Protein Folding
118.2K
Overview
118.2K
03:00Molecular Chaperones and Protein Folding
18.0K
The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
The...
The...
18.0K